The international Stem Cell Medicine Master program offered by Ruhr-University of Bochum invites you to chart the course for the medicine of the future
Your Master in Stem Cell Medicine will prepare your career in one of the most fascinating and promising fields of medicine.
Because Stem cell research is central to our understanding how human life develops as well as leads us to the discovery of novel drugs using stem-cell based disease models and cellular therapies in regenerative medicine. And Cellular reprogramming of somatic cells to induced, pluripotent stem (iPS) cells as well as direct cell transdifferentiations using combinations of transcription factors are the latest developments in these directions.
Therefore we predict that in the near future a strong demand of educated biochemists with backgrounds in stem cell and regenerative medicine will find their places in basic research, medical research institutions, medicinal practice and pharmaceutical industry.
This demands in turn an advanced interdisciplinary educational approach starting in the field of chemistry of small molecules, bioinformatics of nucleic acids and protein networks, biochemistry of transcription factors, genetics and epigenetics, systems biology as well as nanotechnology and material sciences combined with molecular developmental and stem cell medicine training.
The Stem Cell Medicine Master program offered by Ruhr-University of Bochum invites you to chart the course for the medicine of the future, in Stem Cell or regenerative medicine. This is one of the first international master’s programs in stem cell medicine in Germany.
Content of the masters‘ program Stem Cell Medicine
The Stem Cell Medicine Master program offered by Ruhr-University of Bochum is a highly interdisciplinary Master’s programme that is oriented towards cutting-edge biomedical research and current markets (e.g. biotechnology, biomedicine). Our programme combines classical disciplines from the fields of medicine, cell biology, histology, biochemistry and pathology with current topics in molecular biology and developmental biology to offer students the broadest possible understanding of the innovative approaches of translational medicine.
The Modules of the masters‘ program Stem Cell Medicine
Stem Cell Medicine
- Cell cycle control and its implications for stem cell biology
- Principles of vertebrate development
- Gametogenesis and fertilization
- Early development: cleavage, blastocyst, gastrulation
- The three germ layers: ectoderm, mesoderm, endoderm and their derivatives
- Species-specific aspects of development
- Stem cell classification
Stem Cell Biochemistry
- The stem cell niche
- Neural stem cells as a paradigm for stem cell physiology
- Neural development from neural induction to synaptic plasticity
- Signaling processes in stem cells
- Morphogenesis and Tissue Engineering
- Biomaterials in Tissue Engineering
- Stem cells for toxicological and pharmacological assays
- Gene Transfer and Gene Therapy
- Generation of iPS
- Tissue Engineering using Adult Stem Cells / Pluripotent Stem Cells
- Cardiovascular / Hematopoietic Cell Engineering
- Isolation of mesenchymal stem cells from bone marrow aspirate/adipose tissue
- Musculoskeletal / Neural Cell Engineering
- Clinical Experience, Regulations and Ethics
Stem Cell Engineering
- Essentials of cloning in prokaryotic vector systems
- Prokaryotic vector systems, selection modes, cDNA synthesis, ligation, recombination site associated exchange of gene cassettes
- Gene expression in E. coli / Protein analysis
- State of the art sequencing techniques / Epigenetic genome analysis
- In vitro / in vivo mutagenesis
- Gene transfer and expression
- Gene targeting / RNA interference
- Transgenic animals
- RNA methods
- Cell physiology methods
Stem Cell Lecture Series
- Research and Publication Ethics
- Ethical Issues in Biomedical Research
- Cancer / Gene Therapy of Hematopoietic / Induction of pluripotent / Neural Crest-derived / Mesenchymal / Limbal Stem Cells
- Early human Hematopoiesis
- Cell Replacement therapy in the Brain
- Cellular Reprogramming
- Muscle Stem Cells and Myogenesis
- Stem Cell Epigenetics
- Intracellular Signalling in Stem Cells
- Neural Stem Cell Niche
- Cell Migration in Cancer
- Extracellular Vesicles
- Advances in neonatal stem cells research and application
Biomedical Ethics / Legal Aspects
- Introduction to ethics and bioethics
- The moral status of human embryos and fetuses
- Ethical problems of reproductive medicine
- Stem cell research and therapeutic cloning
- Questions of justice and responsibility concerning patents and the protection of intellectual property
- The ethics of clinical trials
- Moral problems of clinical trials involving stem cells
- Security relevant, important parts of GenTG, GenTSV, BioStoffV
- Biosaftey levels of laboratories, technical facilities and working equipment. Licensing procedures according to GenTG
- Important parts of StZG
- Relevant methods available in the lab of choice
- Lab security
- Standards of documentation
- What is a control?
- Structure of research proposals
- Funding agencies
English European language level C1
The contents of this module depend on the choice of host labs. The module provides hands-on experience involving combinations of all techniques taught in the Modules I to V and can thus range from the generation of iPS cells to confocal and/or transmission electron microscopy of mutant or diseased tissues, depending on the interests and profile of the students and the choice of the lab.
Excellent Laboratory facilities for our Students of the Master of Science in Stem Cell Medicine
Stem Cell Medicine Laboratory I
Students Stem Cell Medicine Histology Laboratory I
Study Stem Cell Medicine Cell Culture Laboratory I
Master Stem Cell Medicine Cell Culture Laboratory III
Master Stem Cell Medicine Laboratory IV
Stem Cell Medicine Laboratory I
Master Stem Cell Medicine Cell Culture Laboratory V
Master Stem Cell Medicine Cell Culture Laboratory IV
PD Dr. Holm Zaehres was trained and focused on pluripotent stem cell research at Harvard Medical School Boston and the Max Planck Institute for Molecular Biomedicine Münster after studying in Hamburg and Düsseldorf. He was appointed at Ruhr University Bochum Medical Faculty in 2014, where he is teaching Anatomy, Cell and Molecular Biology.
As a Stem Cell Medicine Graduate you will know the mechanisms of:
action of stem-cell treatments for leukaemia and lymphoma,
application stem-cell therapy e.g. for the management of acute graft-vs-host disease.
As a Stem Cell Medicine Graduate you will perform research to:
prevent conditions such as diabetes and heart diseases,
treat strokes, traumatic brain injuries and neurodegenerative diseases,
to build and replace organs.
(1) Only students who
provide evidence of a bachelor’s degree or an equivalent bachelor’s degree outside of this area of validity in one of the subjects named in paragraph (2).
have a completed Bachelor’s degree with a scope of 210 ECTS can. In the case of admission with a bachelor’s degree of 180 to 209 ECTS, admission is subject to conditions. Students who have completed a bachelor’s degree with less than 180 ECTS cannot be admitted.
be able to demonstrate the best knowledge of cell biology as well as knowledge of molecular biology in theory and practice.
have sufficient knowledge of the English language. This must be proven by TOEFL 95 (internet-based) or IELTS 6.5. The examination board decides on equivalent performance.
have first professional experience of usually not less than 1 year.
(2) Subjects according to Paragraph 1 are Molecular Medicine, Human Medicine, Veterinary Medicine, Dentistry, Pharmacy and comparable specialized courses. The examination board decides on related subjects.